Glial cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Glial cell apoptotic process pathway is significantly associated with the drug response of multiple features, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Staurosporine, WZ3105, and Docetaxel, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Staurosporine grouped by Glial cell apoptotic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Staurosporine →	+0.828	+0.290	.018	.016	3	2
LUNG_NSCLC_LUAD	WZ3105 →	+1.539	+0.290	.027	.016	3	2
LUNG_NSCLC_LUAD	Docetaxel →	+1.255	+0.290	.039	.016	3	1
LUNG_NSCLC_LUAD	Wee1 Inhibitor →	+1.029	+0.290	<.001	.016	3	1
LUNG_NSCLC_LUAD	ZL049 →	+0.668	+0.290	.003	.016	1	3
LUNG_NSCLC_LUAD	FEN1_3940 →	+0.849	+0.335	.008	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Staurosporine by Glial cell apoptotic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →