Response to type III interferon

Across TCGA patient cohorts, RNA activity of the Response to type III interferon pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNRPB, PCNA, and H2AL1RP, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to type III interferon activity versus SNRPB in GBM (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNRPB →	-0.276	-0.539	.006	.006	3	3
GBM	PCNA →	-0.430	-0.511	.001	.007	3	3
PDAC	H2AL1RP →	-0.393	-0.500	<.001	<.001	3	3
BRCA	BMP2K →	+0.376	+0.400	<.001	.002	3	3
BRCA	PUS10 →	+0.384	+0.583	.008	.002	3	3
OV	GLB1L2 →	-0.782	-0.519	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034342 vs SNRPB — GBM

Explore this scatter interactively →