Response to type I interferon

Across TCGA patient cohorts, RNA activity of the Response to type I interferon pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SHFL, SP110_S244, and STAT1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to type I interferon activity versus SHFL in OV (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SHFL →	+0.432	+0.039	.001	<.001	3	10
LSCC	SP110_S244 →	+0.522	+0.059	<.001	<.001	3	10
OV	STAT1 →	+0.670	+0.052	<.001	<.001	3	10
GBM	STAT2 →	+0.378	+0.053	<.001	<.001	3	10
GBM	TRIM21 →	+0.431	+0.070	<.001	<.001	3	10
UCEC	TRIM22 →	+0.559	+0.069	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034340 vs SHFL — OV

Explore this scatter interactively →