Response to type I interferon

Across TCGA patient cohorts, RNA activity of the Response to type I interferon pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SP110, PML, and IGFBP7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to type I interferon activity versus SP110 in PDAC (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SP110 →	+0.346	+0.126	.003	.004	3	5
HNSC	PML →	+0.441	+0.118	.008	.005	3	5
BRCA	IGFBP7 →	-0.630	-0.195	<.001	<.001	3	5
GBM	STAT2 →	+0.370	+0.134	.008	.004	3	5
BRCA	WLS →	-0.719	-0.124	.005	<.001	3	5
BRCA	NDN →	-0.899	-0.150	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034340 vs SP110 — PDAC

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