Response to type I interferon

Across TCGA patient cohorts, RNA activity of the Response to type I interferon pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HSPA12A, IWS1_S263, and YY1AP1_S724, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to type I interferon activity versus HSPA12A in GBM (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HSPA12A →	-0.719	-0.184	<.001	<.001	3	5
GBM	IWS1_S263 →	+1.157	+0.227	<.001	<.001	3	5
GBM	YY1AP1_S724 →	+0.530	+0.190	<.001	<.001	3	5
GBM	TBL3 →	+0.245	+0.211	<.001	<.001	3	4
BRCA	USP10_S576 →	+0.400	+0.166	<.001	<.001	3	4
GBM	HEATR1 →	+0.300	+0.228	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034340 vs HSPA12A — GBM

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