Adherens junction organization

Across TCGA patient cohorts, RNA activity of the Adherens junction organization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BGN, COL1A1, and KANK2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adherens junction organization activity versus BGN in GBM (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BGN →	+0.943	+0.047	<.001	<.001	3	9
BRCA	COL1A1 →	+0.755	+0.029	<.001	<.001	3	8
UCEC	KANK2 →	+0.515	+0.049	<.001	.001	3	8
BRCA	OLFML3 →	+0.689	+0.026	<.001	<.001	3	8
CCRCC	PRELP →	+1.037	+0.066	<.001	<.001	3	8
BRCA	CAVIN2 →	+0.768	+0.027	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034332 vs BGN — GBM

Explore this scatter interactively →