Adherens junction organization

Across TCGA cell cohorts, RNA activity of the Adherens junction organization pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GALNT1, NFIC, and CACTIN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GALNT1 grouped by Adherens junction organization-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GALNT1 →	+0.897	+0.669	.003	.009	3	4
BREAST	NFIC →	-0.634	-0.421	.005	.004	3	4
SKIN	CACTIN →	-0.305	-0.909	.004	.002	3	3
SKIN	CSNK1G2 →	-0.337	-0.844	.007	.002	3	3
LARGE_INTESTINE	MYO5C →	+1.378	+0.631	<.001	.005	3	3
LARGE_INTESTINE	DDAH1 →	+1.369	+0.500	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GALNT1 by Adherens junction organization activity — LARGE_INTESTINE

Explore this box plot interactively →