Adherens junction organization

Across TCGA cell cohorts, RNA activity of the Adherens junction organization pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA3, ALS2CL, and NPTN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adherens junction organization activity versus ANXA3 in STOMACH (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ANXA3 →	+5.581	+0.299	<.001	<.001	3	7
STOMACH	ALS2CL →	+3.426	+0.317	.001	.001	3	7
BLOOD_Lymphoma	NPTN →	+0.953	+0.250	<.001	.005	3	6
STOMACH	LAMB3 →	+4.191	+0.225	<.001	<.001	3	6
BONE	RHBDF1 →	+2.066	+0.410	.003	<.001	3	6
LARGE_INTESTINE	ADGRF1 →	+2.192	+0.208	.002	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034332 vs ANXA3 — STOMACH

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