Cell junction maintenance

Across TCGA cell cohorts, RNA activity of the Cell junction maintenance pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JMJD6, CHORDC1, and CEP164, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell junction maintenance activity versus JMJD6 in BREAST (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	JMJD6 →	-0.794	-1.429	<.001	<.001	3	4
BREAST	CHORDC1 →	-1.270	-0.998	<.001	.002	3	3
BREAST	CEP164 →	-0.870	-0.956	.006	.008	3	3
LUNG_SCLC	MED27 →	-0.663	-1.120	.004	.001	3	3
BREAST	LRATD1 →	+1.427	+1.188	.003	<.001	3	3
BREAST	ZNF202 →	-0.703	-0.875	.006	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034331 vs JMJD6 — BREAST

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