Negative regulation of Arp2/3 complex-mediated actin nucleation

Across TCGA cell cohorts, RNA activity of the Negative regulation of Arp2/3 complex-mediated actin nucleation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FASN, RBM19, and UHMK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FASN grouped by Negative regulation of Arp2/3 complex-mediated actin nucleation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	FASN →	+1.156	+1.170	.001	.005	3	5
OVARY	RBM19 →	+0.690	+0.808	.005	.006	3	4
OVARY	UHMK1 →	-0.817	-1.283	.003	.001	3	4
PANCREAS	HMGXB3 →	-0.619	-1.261	<.001	.001	3	4
LARGE_INTESTINE	HSFX1 →	-0.261	-1.060	.005	<.001	3	3
LARGE_INTESTINE	LAGE3 →	-0.816	-0.919	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FASN by Negative regulation of Arp2/3 complex-mediated actin nucleation activity — LIVER

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