Regulation of Arp2/3 complex-mediated actin nucleation

Across TCGA patient cohorts, RNA activity of the Regulation of Arp2/3 complex-mediated actin nucleation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SND1, COPB2, and EEF2_T57, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Arp2/3 complex-mediated actin nucleation activity versus SND1 in GBM (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SND1 →	-0.233	-0.041	<.001	<.001	3	5
GBM	COPB2 →	-0.211	-0.042	<.001	<.001	3	5
CCRCC	EEF2_T57 →	-0.372	-0.039	<.001	<.001	3	5
CCRCC	FNDC3B →	-0.443	-0.034	<.001	.003	3	5
CCRCC	NRBF2 →	-0.334	-0.037	.004	<.001	3	5
CCRCC	OSTM1 →	-0.293	-0.038	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034315 vs SND1 — GBM

Explore this scatter interactively →