Regulation of Arp2/3 complex-mediated actin nucleation

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of Arp2/3 complex-mediated actin nucleation pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 31 member genes.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher Regulation of Arp2/3 complex-mediated actin nucleation pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and BLCA, show the opposite pattern, with higher activity associated with better survival.

UCS, KIRC, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	III,IV	0.605	0.249	<.001	98	view →
KIRC	DFS	Median	All	0.520	0.689	<.001	95	view →
UVM	OS	Median	III,IV	0.383	0.876	<.001	87	view →
BLCA	OS	Tertile	II,III,IV	0.521	0.349	.009	79	view →
LAML	DFS	Median	All	0.507	0.291	.022	34	view →
LIHC	DFS	Quartile	All	0.387	0.608	<.001	34	view →
SCLC	OS	Tertile	All	0.849	0.541	<.001	31	view →
LUSC	DFS	Median	III,IV	0.544	0.749	.003	19	view →
UCEC	DFS	Median	All	0.558	0.733	.004	18	view →
KICH	OS	Tertile	III,IV	0.301	0.848	.004	12	view →
BRCA	DFS	Median	III,IV	0.929	0.837	.014	11	view →
CHOL	DFS	Quartile	All	0.122	0.457	.021	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0034315–UCS (DFS)

Open the UCS breakdown →