Regulation of Arp2/3 complex-mediated actin nucleation

Across TCGA patient cohorts, RNA activity of the Regulation of Arp2/3 complex-mediated actin nucleation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JADE3, YEATS2, and HDHD5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Arp2/3 complex-mediated actin nucleation activity versus JADE3 in GBM (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	JADE3 →	-0.588	-0.101	.006	.004	3	3
GBM	YEATS2 →	-0.329	-0.137	.004	<.001	3	3
GBM	HDHD5 →	-0.360	-0.109	.002	.003	3	3
LUAD	ARMCX7P →	+0.107	+0.269	.004	.007	3	3
OV	CARMIL1 →	+0.833	+0.434	.002	.008	3	3
PDAC	EEF1A1P14 →	+0.520	+0.286	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034315 vs JADE3 — GBM

Explore this scatter interactively →