Regulation of Arp2/3 complex-mediated actin nucleation

Across TCGA cell cohorts, RNA activity of the Regulation of Arp2/3 complex-mediated actin nucleation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARFIP1, NCKAP1, and ICAM4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARFIP1 grouped by Regulation of Arp2/3 complex-mediated actin nucleation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ARFIP1 →	-0.361	-1.502	.001	<.001	3	5
LARGE_INTESTINE	NCKAP1 →	-0.233	-0.949	.002	<.001	3	5
CNS	ICAM4 →	-0.362	-0.994	.002	.005	3	5
LUNG_NSCLC_LUSC	IRGC →	-0.331	-0.321	.006	.001	3	4
LUNG_NSCLC_LUSC	LRP12 →	-0.181	-0.316	.003	<.001	3	4
SOFT_TISSUE	ENPEP →	+0.332	+1.290	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARFIP1 by Regulation of Arp2/3 complex-mediated actin nucleation activity — BLOOD_Leukemia

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