Regulation of Arp2/3 complex-mediated actin nucleation

Across TCGA cell cohorts, RNA activity of the Regulation of Arp2/3 complex-mediated actin nucleation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPLX4, SF3B5, and PAICS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CPLX4 grouped by Regulation of Arp2/3 complex-mediated actin nucleation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CPLX4 →	-0.032	-1.274	.002	<.001	3	4
LARGE_INTESTINE	SF3B5 →	-0.695	-1.075	.009	.001	3	4
LARGE_INTESTINE	PAICS →	-0.591	-0.824	.004	.003	3	4
LARGE_INTESTINE	COX10 →	-0.763	-1.372	<.001	<.001	3	4
BREAST	MAPRE1 →	+0.612	+0.341	.001	.008	3	3
BLOOD_Leukemia	GPR180 →	+0.639	+1.002	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CPLX4 by Regulation of Arp2/3 complex-mediated actin nucleation activity — OVARY

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