Primary alcohol metabolic process

Across TCGA cell cohorts, RNA activity of the Primary alcohol metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RLBP1, XPA, and AKR1A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RLBP1 grouped by Primary alcohol metabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RLBP1 →	-0.214	-0.877	.001	.004	3	5
LUNG_NSCLC_LUSC	XPA →	+0.154	+1.004	.002	<.001	3	5
STOMACH	AKR1A1 →	-0.356	-1.386	.001	<.001	3	4
OVARY	RBMS2 →	+0.312	+1.364	.002	.001	3	4
CNS	RAB31 →	-0.120	-0.686	.004	<.001	3	4
CNS	DGAT1 →	-0.308	-0.659	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RLBP1 by Primary alcohol metabolic process activity — SKIN

Explore this box plot interactively →