Primary alcohol metabolic process

Across TCGA cell cohorts, RNA activity of the Primary alcohol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H3-3A, EME2, and HIP1R, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, H3-3A grouped by Primary alcohol metabolic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	H3-3A →	-0.776	-1.746	<.001	<.001	3	4
STOMACH	EME2 →	-1.598	-1.284	<.001	.007	3	4
BREAST	HIP1R →	-1.026	-0.696	.004	.004	3	4
BREAST	H2AC18 →	-2.009	-0.564	<.001	.003	3	4
LIVER	SLC44A5 →	-1.493	-0.920	.008	.002	3	3
STOMACH	CFAP44 →	-1.391	-1.481	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

H3-3A by Primary alcohol metabolic process activity — URINARY_TRACT

Explore this box plot interactively →