Response to monosaccharide

Across TCGA patient cohorts, RNA activity of the Response to monosaccharide pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXO3, NR2C2, and PLEKHM3, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to monosaccharide activity versus FOXO3 in THYM (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	FOXO3 →	+1.391	+0.037	<.001	<.001	3	31
THYM	NR2C2 →	+1.251	+0.035	<.001	<.001	3	31
SCLC	PLEKHM3 →	+1.080	+0.057	<.001	<.001	3	31
THYM	ARHGEF12 →	+1.848	+0.043	<.001	<.001	3	31
THYM	BOD1L1 →	+1.272	+0.033	<.001	<.001	3	31
ACC	HERC1 →	+1.082	+0.026	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034284 vs FOXO3 — THYM

Explore this scatter interactively →