Response to monosaccharide

Across TCGA pan-cancer cohorts, RNA activity of the Response to monosaccharide pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 205 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Response to monosaccharide pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SCLC, show the opposite pattern, with higher activity associated with better survival.

HNSC, ACC, and SCLC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.501	0.216	<.001	70	view →
ACC	DFS	Tertile	All	0.253	0.643	<.001	47	view →
SCLC	OS	Quartile	All	0.670	0.221	<.001	47	view →
SKCM	OS	Tertile	III,IV	0.594	0.245	<.001	40	view →
LIHC	OS	Median	All	0.831	0.726	.002	36	view →
MESO	OS	Tertile	All	0.232	0.638	.018	20	view →
LAML	DFS	Tertile	All	0.483	0.680	.019	16	view →
CESC	DFS	Tertile	All	0.721	0.853	.006	12	view →
BLCA	OS	Tertile	III,IV	0.750	0.587	.019	10	view →
PAAD	DFS	Tertile	All	0.366	0.185	.015	10	view →
THYM	DFS	Median	II,III,IV	0.938	0.772	.022	8	view →
ESCA	DFS	Median	III,IV	0.469	0.243	.023	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0034284–HNSC (DFS)

Open the HNSC breakdown →