Response to monosaccharide

Across TCGA patient cohorts, RNA activity of the Response to monosaccharide pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GOLIM4, ZNF43, and SPOUT1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to monosaccharide activity versus GOLIM4 in COAD (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GOLIM4 →	+0.547	+0.121	.002	.004	3	2
COAD	ZNF43 →	+0.741	+0.127	<.001	.004	3	2
COAD	SPOUT1 →	+0.058	+0.177	.001	<.001	3	2
COAD	VN1R51P →	+0.105	+0.144	.002	<.001	3	2
BRCA	COL4A2-AS1 →	+0.882	+0.344	.002	.001	3	2
COAD	ZEB2-AS1 →	+0.095	+0.146	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034284 vs GOLIM4 — COAD

Explore this scatter interactively →