Response to monosaccharide

Across TCGA cell cohorts, RNA activity of the Response to monosaccharide pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF1, TGFBI, and APOL3, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to monosaccharide activity versus IRF1 in BONE (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	IRF1 →	+1.832	+0.131	<.001	<.001	3	12
BONE	TGFBI →	+5.851	+0.128	<.001	<.001	3	12
OVARY	APOL3 →	+1.589	+0.080	<.001	<.001	3	12
BONE	NLRC5 →	+2.094	+0.116	<.001	<.001	3	11
BONE	MICAL2 →	+3.587	+0.114	<.001	<.001	3	11
SOFT_TISSUE	ELL2 →	+2.838	+0.113	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034284 vs IRF1 — BONE

Explore this scatter interactively →