Response to monosaccharide

Across TCGA cell cohorts, RNA activity of the Response to monosaccharide pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UCK2, C1QBP, and VPS53, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to monosaccharide activity versus UCK2 in LUNG_SCLC (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	UCK2 →	-0.689	-0.112	.001	.005	2	7
PANCREAS	C1QBP →	-1.181	-0.464	<.001	<.001	3	5
LIVER	VPS53 →	-0.780	-0.439	.008	.001	3	5
PANCREAS	POP5 →	-0.942	-0.413	<.001	.003	3	5
PANCREAS	BYSL →	-1.187	-0.471	.004	<.001	2	6
PANCREAS	UBR3 →	-0.470	-0.326	.003	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034284 vs UCK2 — LUNG_SCLC

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