tRNA thio-modification

Across TCGA cell cohorts, RNA activity of the tRNA thio-modification pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MPST, AAK1, and TST, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA thio-modification activity versus MPST in LIVER (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MPST →	+1.774	+1.787	.003	.001	3	5
LARGE_INTESTINE	AAK1 →	-1.082	-1.139	<.001	.003	3	5
BLOOD_Leukemia	TST →	+2.369	+1.485	.001	<.001	3	5
LARGE_INTESTINE	COQ8A →	+1.112	+1.294	.004	<.001	3	5
LARGE_INTESTINE	PPFIBP1 →	-1.682	-1.117	.001	.001	3	5
LIVER	ZHX3 →	-1.176	-1.787	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034227 vs MPST — LIVER

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