Acylglycerol transport

Across TCGA patient cohorts, RNA activity of the Acylglycerol transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RSPO1, GLT8D2, and CACNA1C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acylglycerol transport activity versus RSPO1 in BRCA (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RSPO1 →	+0.582	+0.169	.008	<.001	3	5
BRCA	GLT8D2 →	+0.710	+0.125	<.001	.004	3	4
UCEC	CACNA1C →	+0.932	+0.318	.001	.004	3	4
UCEC	CDCA2 →	-0.769	-0.364	<.001	.001	3	4
LUAD	NRAV →	-0.320	-0.237	<.001	.001	3	4
BRCA	ADAM33 →	+0.891	+0.179	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034196 vs RSPO1 — BRCA

Explore this scatter interactively →