Acylglycerol transport

Across TCGA cell cohorts, RNA activity of the Acylglycerol transport pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TDRD6, RAB6C, and IBTK, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TDRD6 grouped by Acylglycerol transport-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TDRD6 →	+0.246	+0.288	.002	.003	3	3
KIDNEY	RAB6C →	-0.178	-0.159	<.001	<.001	3	3
KIDNEY	IBTK →	+0.146	+0.211	.003	.007	3	3
BLOOD_Lymphoma	CORO1C →	+0.580	+0.243	.004	<.001	3	3
BLOOD_Myeloma	DIAPH1 →	+0.333	+0.152	.009	.006	3	3
PANCREAS	THAP12 →	+0.210	+0.192	.009	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TDRD6 by Acylglycerol transport activity — KIDNEY

Explore this box plot interactively →