Positive regulation of toll-like receptor 9 signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of toll-like receptor 9 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRSS16, P3H1, and UAP1L1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRSS16 grouped by Positive regulation of toll-like receptor 9 signaling pathway-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PRSS16 →	+1.736	+1.617	<.001	<.001	3	5
KIDNEY	P3H1 →	-1.101	-1.076	.002	.002	3	5
LIVER	UAP1L1 →	-1.993	-2.360	.009	<.001	3	5
LARGE_INTESTINE	TRPM4 →	+1.142	+0.910	.006	.001	3	4
LARGE_INTESTINE	RAB25 →	+2.977	+0.780	.003	.003	3	4
KIDNEY	EXD3 →	+0.948	+1.215	.007	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRSS16 by Positive regulation of toll-like receptor 9 signaling pathway activity — KIDNEY

Explore this box plot interactively →