Toll-like receptor 9 signaling pathway

Across TCGA patient cohorts, RNA activity of the Toll-like receptor 9 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAT2, PARP14, and ARHGAP30, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Toll-like receptor 9 signaling pathway activity versus STAT2 in COAD (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	STAT2 →	+0.430	+0.035	<.001	<.001	3	10
COAD	PARP14 →	+0.365	+0.033	<.001	<.001	3	10
UCEC	ARHGAP30 →	+0.635	+0.113	<.001	<.001	3	10
COAD	STAT1 →	+0.526	+0.028	<.001	<.001	3	9
UCEC	DOCK10 →	+0.526	+0.087	<.001	.002	3	9
GBM	DOCK2 →	+0.535	+0.079	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034162 vs STAT2 — COAD

Explore this scatter interactively →