Toll-like receptor 9 signaling pathway

Across TCGA cell cohorts, RNA activity of the Toll-like receptor 9 signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD84, SCD, and CDKN2C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD84 grouped by Toll-like receptor 9 signaling pathway-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CD84 →	+0.317	+0.436	.009	<.001	2	4
LUNG_NSCLC_LUAD	SCD →	-0.325	-2.402	.003	<.001	3	2
BLOOD_Lymphoma	CDKN2C →	-0.446	-1.886	<.001	<.001	3	2
BLOOD_Lymphoma	ARHGAP28 →	-0.205	-1.928	.002	.008	3	2
BLOOD_Lymphoma	TRMT2A →	-0.286	-1.886	.002	<.001	3	2
BLOOD_Lymphoma	FBXO5 →	-0.330	-1.886	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD84 by Toll-like receptor 9 signaling pathway activity — BLOOD_Leukemia

Explore this box plot interactively →