Toll-like receptor 8 signaling pathway

Across TCGA patient cohorts, RNA activity of the Toll-like receptor 8 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBMS3-AS1, UCHL1, and OSER1-DT, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Toll-like receptor 8 signaling pathway activity versus RBMS3-AS1 in PDAC (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RBMS3-AS1 →	-0.416	-0.528	.001	<.001	3	4
GBM	UCHL1 →	-0.871	-0.447	<.001	.004	3	4
BRCA	OSER1-DT →	-0.505	-0.574	<.001	<.001	3	3
HNSC	RASA4B →	-0.282	-0.461	.005	.008	3	3
LSCC	PCDHB15 →	-0.383	-0.495	.001	.001	3	3
PDAC	ZSCAN18 →	-0.320	-0.477	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034158 vs RBMS3-AS1 — PDAC

Explore this scatter interactively →