Positive regulation of toll-like receptor 4 signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of toll-like receptor 4 signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS14, HECW2, and RFC4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS14 grouped by Positive regulation of toll-like receptor 4 signaling pathway-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RPS14 →	-0.140	-0.085	.006	.002	3	5
PANCREAS	HECW2 →	-0.312	-0.132	.002	.002	3	4
BREAST	RFC4 →	+0.259	+0.075	.003	.008	3	4
BREAST	POLR1D →	+0.259	+0.080	.001	.007	3	4
BLOOD_Lymphoma	AKT1S1 →	+0.267	+0.093	.009	.001	3	4
LUNG_NSCLC_LUAD	H4C3 →	+0.171	+0.089	.002	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS14 by Positive regulation of toll-like receptor 4 signaling pathway activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →