Positive regulation of toll-like receptor 3 signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of toll-like receptor 3 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AMN1, POLR2M, and ADAM23, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AMN1 grouped by Positive regulation of toll-like receptor 3 signaling pathway-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	AMN1 →	-0.836	-0.929	<.001	.001	3	3
OVARY	POLR2M →	-0.766	-1.027	.001	.005	3	3
BLOOD_Leukemia	ADAM23 →	-0.591	-0.681	.009	.004	3	3
URINARY_TRACT	HNRNPA1 →	-0.816	-2.072	.007	<.001	3	3
BLOOD_Leukemia	TEC →	-2.057	-1.006	<.001	.009	3	3
BLOOD_Myeloma	TXNDC15 →	-1.226	-1.863	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AMN1 by Positive regulation of toll-like receptor 3 signaling pathway activity — CNS

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