Toll-like receptor 3 signaling pathway

Across TCGA cell cohorts, RNA activity of the Toll-like receptor 3 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DAB2, UXT, and SNRPG, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DAB2 grouped by Toll-like receptor 3 signaling pathway-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DAB2 →	-2.114	-1.449	.006	.001	3	6
BREAST	UXT →	-0.722	-1.062	<.001	<.001	3	4
OESOPHAGUS	SNRPG →	-0.486	-0.889	.003	.003	3	4
PANCREAS	CMTM6 →	-0.945	-1.303	.002	.001	3	4
LIVER	C18orf54 →	-0.812	-1.405	<.001	<.001	3	4
LUNG_NSCLC_LUSC	SLC25A16 →	+0.667	+1.019	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DAB2 by Toll-like receptor 3 signaling pathway activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →