Negative regulation of toll-like receptor 2 signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of toll-like receptor 2 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MNDA, SKAP2, and SPN, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of toll-like receptor 2 signaling pathway activity versus MNDA in GBM (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MNDA →	+0.985	+0.119	<.001	<.001	3	9
GBM	SKAP2 →	+0.836	+0.156	<.001	<.001	3	8
PDAC	SPN →	+0.749	+0.077	<.001	<.001	3	8
PDAC	CYBB →	+0.804	+0.074	<.001	<.001	3	8
GBM	AIF1 →	+0.961	+0.153	<.001	<.001	3	8
CCRCC	ITGAL →	+0.761	+0.097	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034136 vs MNDA — GBM

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