Negative regulation of toll-like receptor 2 signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of toll-like receptor 2 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD47, BTBD8, and ARMC10P1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of toll-like receptor 2 signaling pathway activity versus CD47 in HNSC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CD47 →	+0.883	+0.602	<.001	<.001	3	4
LSCC	BTBD8 →	-0.344	-0.326	.009	.006	3	3
LUAD	ARMC10P1 →	+0.153	+0.705	.002	.001	3	3
GBM	PERP →	+0.853	+0.744	<.001	<.001	3	3
BRCA	TRIM60P14 →	+0.071	+0.220	.007	.008	3	3
CCRCC	KPNA2 →	+0.293	+0.444	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034136 vs CD47 — HNSC

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