Regulation of toll-like receptor 2 signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of toll-like receptor 2 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFAIP3, TMEM71, and CEBPB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of toll-like receptor 2 signaling pathway activity versus TNFAIP3 in GBM (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TNFAIP3 →	+1.081	+0.840	<.001	<.001	2	5
GBM	TMEM71 →	+0.768	+0.760	.002	.002	3	4
BRCA	CEBPB →	+0.910	+0.508	<.001	.003	3	4
BRCA	CCR1 →	+1.248	+0.682	<.001	<.001	3	4
BRCA	KBTBD3 →	-0.348	-0.419	.003	.003	3	4
PDAC	TMEM35A →	-0.256	-0.295	.007	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034135 vs TNFAIP3 — GBM

Explore this scatter interactively →