Regulation of toll-like receptor 2 signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of toll-like receptor 2 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPEB2, KYAT1, and TDP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CPEB2 grouped by Regulation of toll-like receptor 2 signaling pathway-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CPEB2 →	-0.899	-0.829	.001	.002	3	4
PANCREAS	KYAT1 →	+0.787	+0.734	<.001	.003	3	3
SKIN	TDP2 →	+0.552	+0.729	<.001	.002	3	3
OVARY	ADAM10 →	-1.237	-0.886	<.001	.002	3	3
OVARY	BAG3 →	-0.882	-0.809	<.001	.006	3	3
OVARY	PELO →	-0.592	-0.626	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CPEB2 by Regulation of toll-like receptor 2 signaling pathway activity — CNS

Explore this box plot interactively →