Regulation of toll-like receptor 2 signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of toll-like receptor 2 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYBA, F2RL1, and HES1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of toll-like receptor 2 signaling pathway activity versus CYBA in BONE (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CYBA →	+3.987	+0.189	<.001	<.001	3	10
URINARY_TRACT	F2RL1 →	+2.026	+0.159	.006	.003	3	9
BONE	HES1 →	+1.902	+0.168	.009	<.001	3	9
OVARY	TNFAIP3 →	+2.015	+0.147	<.001	.001	3	9
BLOOD_Myeloma	TLR6 →	-1.236	-0.151	<.001	<.001	3	8
STOMACH	MFHAS1 →	+1.455	+0.174	<.001	.002	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034135 vs CYBA — BONE

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