Positive regulation of heterotypic cell-cell adhesion

Across TCGA patient cohorts, RNA activity of the Positive regulation of heterotypic cell-cell adhesion pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DEF6, MNDA, and LSP1_S208, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of heterotypic cell-cell adhesion activity versus DEF6 in CCRCC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DEF6 →	+0.428	+0.120	<.001	<.001	3	8
OV	MNDA →	+0.668	+0.046	<.001	<.001	3	8
LSCC	LSP1_S208 →	+0.863	+0.096	<.001	<.001	3	7
OV	SKAP2 →	+0.654	+0.068	<.001	<.001	3	7
LSCC	CYBA →	+0.601	+0.084	<.001	<.001	3	7
OV	CYBB →	+0.692	+0.061	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034116 vs DEF6 — CCRCC

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