Regulation of heterotypic cell-cell adhesion

Across TCGA patient cohorts, RNA activity of the Regulation of heterotypic cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEACAM4, CSF3R, and PLEK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of heterotypic cell-cell adhesion activity versus CEACAM4 in GBM (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CEACAM4 →	+0.619	+0.264	.005	.004	3	6
GBM	CSF3R →	+0.869	+0.414	<.001	<.001	3	6
GBM	PLEK →	+0.806	+0.253	<.001	<.001	3	5
GBM	GPR65 →	+0.505	+0.200	.002	.002	3	5
UCEC	SAMSN1 →	+0.753	+0.345	<.001	.002	3	5
GBM	NLRP3 →	+0.750	+0.275	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034114 vs CEACAM4 — GBM

Explore this scatter interactively →