Heterotypic cell-cell adhesion

Across TCGA patient cohorts, RNA activity of the Heterotypic cell-cell adhesion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATP1A1, DSC2, and DSP_S176, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heterotypic cell-cell adhesion activity versus ATP1A1 in GBM (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ATP1A1 →	+0.616	+0.364	<.001	<.001	3	5
HNSC	DSC2 →	+0.770	+0.254	<.001	<.001	3	5
BRCA	DSP_S176 →	+1.097	+0.201	<.001	<.001	3	5
OV	DSP_S22 →	+0.610	+0.267	.005	<.001	3	5
OV	ATP1A1_S16 →	+0.788	+0.245	<.001	.001	3	5
BRCA	CASC3 →	-0.275	-0.160	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034113 vs ATP1A1 — GBM

Explore this scatter interactively →