Negative regulation of homotypic cell-cell adhesion

Across TCGA patient cohorts, RNA activity of the Negative regulation of homotypic cell-cell adhesion pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PDLIM7, PRKG1, and VCL, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of homotypic cell-cell adhesion activity versus PDLIM7 in OV (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PDLIM7 →	+0.705	+0.057	<.001	.001	3	8
UCEC	PRKG1 →	+0.543	+0.053	.004	.009	3	8
COAD	VCL →	+0.415	+0.033	<.001	.003	3	7
OV	C1S →	+0.654	+0.045	<.001	.003	3	7
OV	COL1A2 →	+0.604	+0.041	.002	.003	3	7
BRCA	COL5A1 →	+0.759	+0.037	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034111 vs PDLIM7 — OV

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