Negative regulation of homotypic cell-cell adhesion

Across TCGA patient cohorts, RNA activity of the Negative regulation of homotypic cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXS1, FFAR4, and ITGBL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of homotypic cell-cell adhesion activity versus FOXS1 in PDAC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	FOXS1 →	+0.720	+0.257	<.001	<.001	3	5
PDAC	FFAR4 →	+0.498	+0.177	<.001	<.001	3	5
PDAC	ITGBL1 →	+0.817	+0.238	<.001	<.001	3	5
GBM	SERPINF1 →	+0.904	+0.318	<.001	<.001	3	5
BRCA	CHEK1 →	-0.757	-0.300	.001	.001	3	5
LSCC	DTL →	-0.548	-0.129	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034111 vs FOXS1 — PDAC

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