Negative regulation of homotypic cell-cell adhesion

Across TCGA cell cohorts, RNA activity of the Negative regulation of homotypic cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACAD10, NFIL3, and PUSL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of homotypic cell-cell adhesion activity versus ACAD10 in BLOOD_Myeloma (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ACAD10 →	+1.290	+0.249	.006	.004	3	5
OESOPHAGUS	NFIL3 →	-0.801	-0.243	.001	.001	3	4
SOFT_TISSUE	PUSL1 →	-1.117	-0.247	.003	.002	3	4
SKIN	CITED2 →	+1.291	+0.368	.002	<.001	3	4
LUNG_SCLC	ITIH4 →	+0.932	+0.215	<.001	.007	3	4
BLOOD_Myeloma	AP3S1 →	+1.201	+0.243	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034111 vs ACAD10 — BLOOD_Myeloma

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