Regulation of homotypic cell-cell adhesion

Across TCGA patient cohorts, RNA activity of the Regulation of homotypic cell-cell adhesion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IL16, SYNPO2, and AKAP12, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of homotypic cell-cell adhesion activity versus IL16 in GBM (Pearson r = 0.74).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IL16 →	+0.700	+0.087	<.001	<.001	3	10
HNSC	SYNPO2 →	+1.066	+0.062	<.001	<.001	3	9
COAD	AKAP12 →	+0.905	+0.043	<.001	<.001	3	9
UCEC	ABI3BP →	+0.792	+0.066	<.001	<.001	3	9
LSCC	ANKRD44 →	+0.317	+0.060	<.001	<.001	3	9
GBM	RCSD1 →	+0.635	+0.087	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034110 vs IL16 — GBM

Explore this scatter interactively →