Regulation of homotypic cell-cell adhesion

Across TCGA cell cohorts, RNA activity of the Regulation of homotypic cell-cell adhesion pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCD, MYF6, and SERPINE2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRKCD grouped by Regulation of homotypic cell-cell adhesion-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PRKCD →	-0.172	-0.705	.005	<.001	3	5
SOFT_TISSUE	MYF6 →	-0.392	-0.978	<.001	.003	3	4
BLOOD_Myeloma	SERPINE2 →	-0.327	-1.830	.004	<.001	3	4
OVARY	NINJ2 →	-0.262	-0.913	.006	.003	3	4
BONE	RET →	-0.195	-1.042	.002	.005	3	4
LUNG_NSCLC_LUAD	HMX3 →	+0.175	+0.549	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRKCD by Regulation of homotypic cell-cell adhesion activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →