Positive regulation of tissue remodeling

Across TCGA patient cohorts, RNA activity of the Positive regulation of tissue remodeling pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRKG1, U2SURP_S67, and VRK3_S136, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of tissue remodeling activity versus PRKG1 in LSCC (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PRKG1 →	+0.296	+0.071	.008	.004	3	6
LUAD	U2SURP_S67 →	-0.475	-0.065	<.001	<.001	3	5
UCEC	VRK3_S136 →	-0.604	-0.092	.002	.001	3	5
UCEC	C1orf116 →	+0.785	+0.095	.005	.002	3	5
LSCC	CAST →	+0.327	+0.088	.002	<.001	3	5
LUAD	DNMT1_S714 →	-0.419	-0.050	.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034105 vs PRKG1 — LSCC

Explore this scatter interactively →