Positive regulation of tissue remodeling

Across TCGA cell cohorts, RNA activity of the Positive regulation of tissue remodeling pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NABP1, RPP40, and PTGS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NABP1 grouped by Positive regulation of tissue remodeling-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NABP1 →	-1.856	-1.223	.001	.001	3	4
LARGE_INTESTINE	RPP40 →	+0.726	+1.061	.002	.001	3	4
LARGE_INTESTINE	PTGS2 →	-1.378	-0.803	.009	.006	3	4
BLOOD_Leukemia	ANKMY2 →	-0.824	-0.962	<.001	.005	3	3
BLOOD_Leukemia	CCDC93 →	-0.752	-0.874	.004	.004	2	4
BLOOD_Leukemia	PML →	-0.694	-1.261	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NABP1 by Positive regulation of tissue remodeling activity — LUNG_SCLC

Explore this box plot interactively →