Positive regulation of tissue remodeling

Across TCGA cell cohorts, RNA activity of the Positive regulation of tissue remodeling pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF144A, BEND7, and LUZP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of tissue remodeling activity versus RNF144A in PANCREAS (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RNF144A →	+1.362	+1.516	.007	<.001	3	4
PANCREAS	BEND7 →	+1.943	+1.602	.002	<.001	3	4
BLOOD_Leukemia	LUZP1 →	+0.845	+0.937	.004	.008	2	5
OVARY	IL18 →	+2.343	+1.459	<.001	.001	3	4
BLOOD_Leukemia	ZBED3 →	+1.859	+1.152	<.001	.001	3	3
PANCREAS	FAM83F →	-1.836	-1.796	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034105 vs RNF144A — PANCREAS

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