Erythrocyte homeostasis

Across TCGA cell cohorts, RNA activity of the Erythrocyte homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFYVE19, BAX, and RPN2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Erythrocyte homeostasis activity versus ZFYVE19 in BLOOD_Leukemia (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZFYVE19 →	+0.421	+0.161	.003	<.001	2	6
OVARY	BAX →	-1.523	-0.235	.001	<.001	3	5
BREAST	RPN2 →	+1.008	+0.219	.004	.001	3	4
LUNG_SCLC	IFITM3 →	+2.802	+0.171	.005	.007	3	4
STOMACH	IBTK →	+0.971	+0.186	.007	.008	3	4
SOFT_TISSUE	DBNDD1 →	-1.510	-0.174	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034101 vs ZFYVE19 — BLOOD_Leukemia

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