Positive regulation of maintenance of sister chromatid cohesion

Across TCGA patient cohorts, RNA activity of the Positive regulation of maintenance of sister chromatid cohesion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, MKI67, and TOP2A, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of maintenance of sister chromatid cohesion activity versus SMC2 in GBM (Pearson r = 0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC2 →	+0.550	+0.073	<.001	<.001	3	10
LUAD	MKI67 →	+0.700	+0.115	<.001	<.001	3	10
LUAD	TOP2A →	+0.842	+0.107	<.001	<.001	3	9
LUAD	KIF11_T926 →	+0.993	+0.103	<.001	<.001	3	9
BRCA	NPM1_S254 →	+0.969	+0.041	.001	.001	3	9
LUAD	NPM1_T199 →	+1.315	+0.061	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034093 vs SMC2 — GBM

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